What Every Midlife Woman Should Know About Peptides
Midlife comes with a few plot twists. Slower metabolism. Creeping inflammation. Skin changes. Stubborn belly fluff that laughs in the face of your “clean eating.”
If you’ve been doing all the things: eating whole foods, lifting weights, sleeping like it’s your job and you still feel like you’re treading water, you’re not broken.
Your biology just needs a little backup.
That’s where peptides come in.
What Are Peptides?
Peptides are short chains of amino acids that act like little messengers in your body, telling your cells to do helpful things—like build collagen, repair tissues, regulate hormones, and burn fat more efficiently.
They're naturally occurring, and your body makes less of them as you age (of course it does 🙄). So supplementing them is like giving your system a gentle nudge to get back on track.
Should Menopausal Women Take Peptides?
Uh, heck yeah!
I’ve eaten clean for a very long time and done all the lifestyle things (I do love the health gadgets - sauna blanket ✅, vibration plate ✅, red light therapy ✅, Apollo Bracelet ✅). But by 55 (5 years post-menopause), I still felt off.
a little inflammed
a belly bulge that refused to budge.
constant food noise that was driving my day.
Peptides were the first thing that helped calm my inflammation, quiet my cravings, and finally shift my metabolism. I’m lucky, I didn’t need to lose a lot of weight, but I dropped 6 lbs in 6 weeks without changing anything else except add a GLP/GIP (Tirzepatide), and it was the first time I felt like my body was working with me again.
What are the best peptides for women over 50?
These are a few of the peptides that I personally use or have used that I feel like are helping me get through the midlife chaos and feel like I’m not working SO damn hard just to stay at my best.
1. Semaglutide or Tirzepatide (GLP-1/GIP)
Works for:
Weight management
Blood sugar control / Insulin Resistance
Reducing cravings / eliminating food noise
Supporting cardiovascular health
Works well if you’re on the “healthy but stuck” plateau
Especially helpful if your metabolism has slowed or you’re dealing with insulin resistance.
GLP-1 peptides do more than support weight loss. They’ve been shown to significantly reduce heart attack and stroke risk, especially in midlife women.
➡️ Cardiovascular disease is still the #1 cause of death in women, responsible for about 1 in every 5 female deaths in the U.S. annually .
➡️ Heart attacks are increasing in younger women (ages 35–54) even while they decline in older men .
So this next part matters…
In the SELECT trial, which studied over 17,000 people with obesity (but without diabetes), semaglutide reduced major cardiovascular events (heart attack, stroke, and CV-related death) by 20%, even when weight loss was minimal.
👉 In fact, only about a third of the cardiovascular benefit could be explained by weight loss. The rest came from direct effects on blood pressure, inflammation, and vascular health .
Translation: These peptides help your whole system function better—not just your waistline.
2. BPC-157
Works for:
Gut healing (leaky gut, reflux, food sensitivities)
Chronic pain or joint inflammation
Recovery after injury or surgery
A go-to for women dealing with low-grade inflammation or mystery aches and pains.
3. GHK-Cu (Copper Peptide)
Works for:
Collagen production
Hair regrowth
Skin firmness + elasticity
This is a good one to cycle a few times a year for anyone over 40.
4. Tesamorelin / CJC-1295 / Ipamorelin (Growth Hormone Secretagogues)
These are not growth hormones. They give the pituitary the nudge to release growth hormones. You will commonly find these in blends like Tesamorelin/Ipamorelin.
Works for:
Supporting growth hormone levels naturally
Building or keeping muscle while on a GLP/GIP
Better sleep, muscle tone, and recovery
Note: This one may require practitioner support, but can be powerful for women struggling with strength, body comp, or recovery. Contraindicated for anyone with cancer or a history of cancer.
5. Thymosin Alpha-1
Acute immune stimulator (“I need help right now”); boosts T-cell function and antiviral responses, Best when you’re sick (COVID, flu), traveling, about to undergo surgery, or dealing with a major stressor.
Works for:
calming down or controlling flares by ramping immune function appropriately
Can be used short-term (1–4 weeks) during active immune challenges
managine autoimmune flares
But First: The Foundations Matter
Before you run off to order a peptide protocol, let’s talk about what has to be in place for these to work optimally. You can definitely hop on a GLP-1 not change anything and lose weight, but you will not be getting your full money’s worth if you don’t get these dialed in:
✔️ Diet – Nutrient-dense, blood sugar-balanced, food that fuels you
✔️ Rest – No healing happens when you’re chronically exhausted
✔️ Exercise – Especially resistance training. Muscle = metabolism
✔️ Stress Management – Cortisol will hijack everything if left unchecked
Peptides can enhance what you’re doing—but they don’t replace the work.
Just remember: Peptides are tools, not magic. You’ll get the best results when you’re getting those foundations down
and working with someone who understands your midlife body.
Curious if peptides could help you?
I’m happy to share more about how I use them in my own routine or guide you through getting started with a trusted source.
📞 Book a discovery call and let’s chat about what’s right for you.
This information is for educational purposes only and is not intended to diagnose, treat, or cure any condition. Always consult with a licensed healthcare provider before starting any new supplement, medication, or health protocol. GLP-1s are FDA-approved for specific conditions, but microdosing is considered off-label.